Abstract: To fundamentally eliminate potential safety hazards, reduce occupational health risks, improve the on-site environment of coal slime flotation, enhance flotation efficiency and resource utilization, and fundamentally resolve the issue of "heavy medium ash carry-over" caused by fluctuations in clean coal ash content, this study adhered to the principles of safety, environmental protection, efficiency, and economy. Through comparative laboratory-scale flotation tests and industrial trials on coal slime at Shaqu Coal Preparation Plant, the physicochemical properties of the new collector DVS4U058 and frother N88050 were investigated to verify their adaptability, separation efficiency, and economic feasibility. The results demonstrated that DVS4U058 and N88050 fully comply with green standards for coal flotation reagents. Their enhanced safety and environmental performance better ensured safe production and improved the operational environment during flotation, while exhibiting higher selectivity. The comprehensive unit consumption of reagents decreased by 28.57% year-on-year, the clean coal yield increased by 2.59 percentage points, the standard deviation of clean coal ash content was only 0.11%, and the tailings ash content increased by 1.98 percentage points. Compared with the existing process, the annual sales revenue could increase by 8.8456 million yuan, demonstrating significant environmental and economic benefits.